mavorixafor will boost the stage or effect of codeine by impacting hepatic enzyme CYP2D6 metabolism. Contraindicated. Mavorixafor (a solid CYP2D6 inhibitor) is contraindicated with prescription drugs which have been extremely dependent on CYP2D6 for clearance.benzhydrocodone/acetaminophen and codeine both boost sedation. Steer clear of or Use Alter